Compliance with federal law is mandated for all vehicles or combinations of vehicles operating on interstate or national defense highways, with their weight not exceeding the maximum allowed and in alignment with the axle load limitation. This alignment is based on Table I, corresponding to the distance in feet between the extremes of any axle groups, measured longitudinally to the nearest foot. Exceptions are granted for vehicles with two consecutive sets of tandem axles, allowing a gross load of thirty-six thousand (36,000) pounds each, provided the distance between the first and last axles of the tandem sets is thirty-six (36) feet or more. Prior permission in the form of a permit is required for vehicles exceeding legal size or weight limits before operating on any Wyoming State Highway.

In the event that a hauling truck surpasses weight limitations, it may be permitted to unload at its destination within Wyoming if the destination is within one (1) mile of the truck's location when the violation was identified, unless there is an immediate public safety concern. The initial violation incurs no penalty, but subsequent violations are subject to the penalty provisions of W.S. 31-18-805. Failure to comply with weight regulations may result in fines starting at $120.

The uniform schedule for deposits for appearances related to commercial vehicle violations, established either by court rule or statutory authority, includes $20.00 for Court Costs, $10.00 for a Court Automation Fee, and a $10.00 civil legal services fee.